Is terbinafine metabolized by the liver?
While terbinafine is metabolized extensively in the liver, this occurs via the action of various P-450 enzymes (eg, CYP2C9, CYP1A2, CYP3A4, CYP2C8, and CYP2C19) (Vickers et al 1999).
What is the MOA of terbinafine?
Abstract. Terbinafine (Lamisil) has primarily fungicidal action against many fungi as a result of its specific mechanism of squalene epoxidase inhibition. Treated fungi accumulate squalene while becoming deficient in ergosterol, an essential component of fungal cell membranes.
How do I know if terbinafine is affecting my liver?
Despite its rarity, patients taking terbinafine who exhibit any of the symptoms of liver problems (nausea, vomiting, abdominal pain, fatigue, anorexia, general itching and dark urine) should urgently be referred for further assessment.
What are some side effects of terbinafine?
Terbinafine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea.
- indigestion.
- itching.
- headache.
- feeling sad, worthless, restless, or other changes in mood.
- loss of energy or interest in daily activities.
- changes in how you sleep.
When is the best time to take terbinafine?
Timing: Take terbinafine tablets at the same time each day, either in the morning OR in the evening. You can take terbinafine with or without food. Missed dose: If you forget to take your dose, take it as soon as you remember that day.
Is terbinafine 250 mg safe?
Terbinafine (250 mg/day): an effective and safe treatment of cutaneous sporotrichosis.
Is terbinafine safe to take?
For some infections, such as fungal nail infections, you may need to take terbinafine tablets for up to 3 months (sometimes longer). It is safe to take long-term if your doctor tells you to.
How long can terbinafine be taken?
The dose is usually 250 milligrams (mg) once a day for 6 weeks. Children 4 years of age and older and weighing over 35 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is usually 250 mg once a day for 6 weeks.
How fast does terbinafine work?
Terbinafine solution usually starts to work within a few days. Talk to your doctor if your symptoms do not get better within 1 week. The cream, gel or spray usually starts to work within a few days. Talk to your doctor if your symptoms do not get better within 2 weeks.
What are the side effects of taking terbinafine?
Common side effects of terbinafine may include: diarrhea, nausea, gas, stomach pain or upset; rash; headache; abnormal liver function tests.
What is the best time of day to take terbinafine?
How do I know if terbinafine is working?