Is Methotrexate a pyrimidine antagonist?
Drugs in the category include methotrexate and 5-fluorouracil (folic acid antagonists); azathioprine, mercaptopurine, and 6-thioguanine (purine antagonists); and cytosine arabinoside and gemcitabine (pyrimidine antagonists).
Which one of the following is pyrimidine antagonist used as anticancer?
The pyrimidine antagonist, cytarabine (also called cytosine arabinoside), is used to treat leukemia or non-Hodgkin lymphoma.
Which of the following is six purine antagonist?
Azathioprine (Imuran) Azathioprine (AZA) is a pro-drug that is metabolized to its active component 6-mercaptopurine (6-MP), a purine antagonist that inhibits DNA synthesis and lymphocyte proliferation.
What is a pyrimidine analog chemotherapy drug?
The pyrimidine analogs are S-phase-specific drugs that include fluorouracil and cytarabine. Fluorouracil is a fluorinated pyrimidine that becomes phosphorylated intracellularly and then binds covalently with thymidylate synthetase, thereby inhibiting its action and interfering with DNA and RNA synthesis (see Fig.
What is folate antagonism?
A type of drug that stops cells from using folic acid to make DNA and may kill cancer cells. Certain folate antagonists are used to treat some types of cancer and inflammatory conditions, such as rheumatoid arthritis. Also called antifolate and folic acid antagonist.
What is purine and pyrimidine analogues?
The basic mechanism of action of purine and pyrimidine antimetabolites is similar. These compounds diffuse into cells (usually with the aid of a membrane transporter1) and are converted to analogues of cellular nucleotides by enzymes of the purine or pyrimidine metabolic pathway.
Which of the following is a pyrimidine analogue?
Pyrimidine analogs include 5-fluorouracil, cytosine arabinoside, 5-azacytidine, and gemcitabine.
What class is hydroxychloroquine?
Hydroxychloroquine is in a class of drugs called antimalarials. It works by killing the organisms that cause malaria. Hydroxychloroquine may work to treat rheumatoid arthritis and systemic lupus erythematosus by decreasing the activity of the immune system.
How do pyrimidine antagonists work?
The pyrimidine antagonists act to block the synthesis of pyrimidine containing nucleotides (C and T in DNA; C and U in RNA). The drugs used to block the construction of these nucleotides have structures that are similar to the natural compound.
What is mitomycin C used for?
Mitomycin C is an antimetabolite applied between the sclera and conjunctiva during the initial stages of a trabeculectomy to prevent excessive post-operative scarring and thus reduce the risk of failure.
Why cisplatin is used as an anticancer drug?
Cisplatin binds to the N7 reactive center on purine residues and as such can cause deoxyribonucleic acid (DNA) damage in cancer cells, blocking cell division and resulting in apoptotic cell death.
What is doxorubicin for?
Doxorubicin injection is used together with other medicines to treat cancer of the blood, lymph system, bladder, breast, stomach, lungs, ovaries, thyroid, nerves, kidneys, bones, and soft tissues, including muscles and tendons. It may also be used to treat other kinds of cancer, as determined by your doctor.
Is Cipro a folate antagonist?
Tetrahydrofolic acid is the physiologically active form of folic acid and is required as a cofactor in synthesis of thymidine, purines, and bacterial DNA….Chapter 48 Bacterial Folate Antagonists, Fluoroquinolones, and Other Antibacterial Agents.
| Disease | Recommendations |
|---|---|
| Gram-negative bacterial infections | Ciprofloxacin |