When do you give dexrazoxane?
In this setting, dexrazoxane is administered as an intravenous infusion 10–30 minutes before the anthracycline. The benefit–risk balance of dexrazoxane in children and adolescents is presently generally considered to be unfavorable. The indication is prevention of tissue injuries from extravasation of anthracyclines.
How much does dexrazoxane cost?
The cost for dexrazoxane intravenous powder for injection 500 mg is around $416 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How do you give dexrazoxane?
Dexrazoxane injection comes as a powder to be mixed with liquid and injected into a vein by a doctor or nurse in a hospital. When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given over 15 minutes just before each dose of doxorubicin.
What is the antidote for anthracycline extravasation?
Preclinical and clinical studies are leading to the clinical implementation of dexrazoxane as the first and only proven antidote in anthracycline extravasation. In two multicenter studies dexrazoxane has proven to be highly effective in preventing skin necrosis and ulceration.
Is dexrazoxane a chemo?
Doxorubicin forms free radicals which can be harmful to your heart if you are exposed to high enough doses of doxorubicin, Dexrazoxane, a chemoprotectant, is thought to bind to the free radicals formed by doxorubicin limiting their harmful effects and protecting your heart.
Is dexrazoxane FDA approved?
On September 6, 2007, the U.S. Food and Drug Administration approved Totect 500 mg (dexrazoxane hydrochloride for injection) for the treatment of extravasation resulting from i.v. anthracycline chemotherapy.
What chemo drugs cause extravasation?
Vinca alkaloids: Vinca alkaloids, which include vinblastine, vincristine, and vinorelbine, can cause direct cellular damage upon extravasation.
What class of drug is doxorubicin?
Doxorubicin is in a class of medications called anthracyclines. It works by slowing or stopping the growth of cancer cells in your body.
Who makes docetaxel?
Docetaxel is marketed worldwide under the name Taxotere by Sanofi-Aventis as well as Docefrez by Sun Pharma Global and Zytax by Zydus.
How do I administer Zinecard?
Administer ZINECARD Injection via intravenous infusion over 15 minutes. DO NOT ADMINISTER VIA AN INTRAVENOUS PUSH. The recommended dosage ratio of ZINECARD to doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD to 50 mg/m2 doxorubicin).
What is the second step to treating an extravasation?
If extravasation occurs, the injection should be stopped immediately and the IV tubing disconnected. Avoid applying pressure to the site, and do not flush the line. Leave the original catheter in place, and attempt to aspirate as much of the infiltrated drug as possible.
What is difference between extravasation and infiltration?
The difference between an infiltration and extravasation is the type of medicine or fluid that is leaked. Infiltration – if the fluid is a non-vesicant (does not irritate tissue), it is called an infiltration. Extravasation – if the fluid is a vesicant (a fluid that irritates tissue), it is called an extravasation.
What is the best method of extravasation prevention?
Apply either ice packs or warm compresses to the affected area, depending on the type of vesicant. For most extravasations, you’ll apply ice for 20 minutes four to six times a day for 24 to 48 hours.
What is the cost of doxorubicin?
The cost for doxorubicin liposomal intravenous dispersion (2 mg/mL) is around $618 for a supply of 10 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What is the cost of docetaxel?
Docetaxel is the generic version of Taxotere. The average cost of Taxotere is around $609 for a supply of 1 ml, 20 mg/mL intravenous solution.
What is an availability form?
An availability form is a document which is used by organizations and institutions to record the availability of a specific item, person, or schedule. The form allows the organization to determine the actions to be taken if unavailability is reported.
What are the advantages of PDF availability forms?
Compared to other formats, availability forms in PDF formats are easy to fill out since there are entry fields of where the data must be placed. Another advantage of this format is that it is accessible and also shows and retains the actual document layout even if it will be sent or will be transferred from one device to another.
Who are the target users of copyright and availability forms?
Copyright and Availability Form – Electronic theses and dissertation’s publishers are the target users of copyright and availability forms. Basically, the publisher or the researcher of the theses will be able to state his name, identification number, degree, and the availability of his publication in the form.