What is action of digitoxin is phytochemical?
Digitoxin is a lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels.
What is the difference between digoxin and Digitoxin?
Digitoxin is a cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting (From Martindale, The Extra Pharmacopoeia, 30th ed, p665).
Which drug found to contain digitoxin*?
Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting….Digitoxin.
| Clinical data | |
|---|---|
| CAS Number | 71-63-6 |
| PubChem CID | 441207 |
| IUPHAR/BPS | 6782 |
| DrugBank | DB01396 |
What are digitoxin?
Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.
Is digitoxin soluble in water?
Digitoxin is a cardiac glycoside. Solubility : Soluble in alcohol (16.67 mg/ml), chloroform (25 mg/ml), acetone, and methanol (partially). Insoluble in water.
What is the mechanism of action of digitoxin?
Digoxin has two principal mechanisms of action which are selectively employed depending on the indication: Positive Ionotropic: It increases the force of contraction of the heart by reversibly inhibiting the activity of the myocardial Na-K ATPase pump, an enzyme that controls the movement of ions into the heart.
Does digoxin increase or decrease potassium levels?
Pathophysiology – Digoxin Toxicity Digoxin toxicity causes hyperkalemia, or high potassium. The sodium/potassium ATPase pump normally causes sodium to leave cells and potassium to enter cells. Blocking this mechanism results in higher serum potassium levels.
Is digitalis and digitoxin same?
Digoxin (better known as Digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is one of the oldest medications used in the field of cardiology.
Is digoxin water soluble?
Digoxin exists as odorless white crystals that melt with decomposition above 230°C. The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and in chloroform; and freely soluble in pyridine.
What does digoxin do to potassium?
(1) Digoxin inhibits the cardiac Na/K antiporter (orange oval, above). This causes an increase in intracellular sodium and a decrease in intracellular potassium. The decrease in intracellular potassium is what causes hyperkalemia in patients with digoxin overdose.
Is digoxin hydrophilic?
Digoxin is highly hydrophilic and the dose-effect relationship is dependent on lean body mass; dosage should be based on ideal body weight.
How is digoxin metabolised?
The main route of elimination is renal excretion of digoxin, which is closely correlated with the glomerular filtration rate. In addition, some tubular secretion and perhaps tubular reabsorption occurs. Nearly all of the digoxin in the urine is excreted unchanged, with a small part as active metabolites.
Why does digoxin increase potassium?
How does digoxin affect electrolytes?
Electrolyte disturbances such as hypomagnesemia, hypercalcemia, and hypokalemia lead to increased sensitivity to digoxin making toxicity more likely even with a lower concentration of serum digoxin. This makes diagnosis difficult and has led to the declining use of digoxin over the last several years.
Is digoxin water or lipid soluble?
Water soluble drugs (like digoxin) will show a small volume of distribution (V), increased plasma concentrations with reduced total body water and, thus, accommodation needs to be made in reducing loading doses [8,11,14].
What electrolyte should be monitored with digoxin?
Electrolyte disturbances such as hypomagnesemia, hypercalcemia, and hypokalemia lead to increased sensitivity to digoxin making toxicity more likely even with a lower concentration of serum digoxin.