What are the side effects of inhaling chloroform?
Local effects following inhalation of chloroform include shortness of breath and irritation of the nose and throat. Acute inhalation can cause systemic effects such as, excitement, nausea and vomiting followed by ataxia, dizziness, drowsiness.
What is the biotransformation of chloroform?
The oxidative biotransformation of chloroform is catalysed by cytochrome P-450 to produce trichloromethanol. Loss of HCl from trichloromethanol produces phosgene as a reactive intermediate.
What is the use of chloroform in hospital?
Chloroform: A clear, volatile liquid with a strong smell similar to that of ether. Chloroform was once administered by inhalation to produce anesthesia, given to relieve pain, and used as a remedy for cough. It is quite toxic to the kidneys and the liver.
What is the mechanism of toxicity of chloroform?
Bioactivation of chloroform and carbon tetrachloride. The mechanism of chloroform nephrotoxicity involves the oxidation of chloroform to trichloromethanol by renal cytochrome P-450 isozymes such as CYP2E1 (Figure 6). The trichloromethanol readily eliminates HCl to form the highly reactive toxicant phosgene (COCl2).
Does chloroform damage the brain?
Breathing air with chloroform for a short time causes headache, fatigue and dizziness. Breathing air with chloroform for a long period damages the brain, liver and kidneys. It may cause cancer.
Is chloroform harmful to the body?
Chronic (long-term) exposure to chloroform by inhalation in humans has resulted in effects on the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability.
Is chloroform a CNS depressant?
Chloroform is a potent central nervous system and respiratory depressant. The toxicities associated with chloroform frequently occur after inhalation.
Can you drink chloroform?
Ingestion of chloroform can cause a burning sensation in the mouth and throat, nausea and vomiting. Chloroform can be absorbed into the body via ingestion or inhalation. Symptoms include excitement and nausea followed by dizziness and drowsiness.
Is chloroform safe for humans?
Chloroform (CHCl3) is a colorless liquid that quickly evaporates into gas. It can harm the eyes, skin, liver, kidneys, and nervous system. Chloroform can be toxic if inhaled or swallowed. Exposure to chloroform may also cause cancer.
What is antidote of chloroform?
HYDROCYANIC ACID AS AN ANTIDOTE IN CHLOROFORM POISONING.
What happens if you inject chloroform?
Bone and soft tissue necrosis, tooth loss, and sensory nerve damage (anesthesia and paresthesia) were the most common consequences reported.
Can you smell chloroform?
Most people can’t smell chloroform until levels reach 133,000 ppbv or higher. If you can smell the chemical, the level is too high to be safe.
Who uses chloroform?
Chloroform is often used as a solvent in the chemical production of compounds. It is used in the paper, construction and woodworking industries. It is used in pesticide and film production. Chloroform is used to produce a refrigerant called Fluorocarbon 22.
Does chloroform cause memory loss?
Chronic exposure to chloroform may produce dizziness, fatigue, drowsiness, memory impairment, increased dreams, anorexia and palpitations.
Is it legal to have chloroform?
Although synthesizing chloroform requires the sophisticated knowledge of a chemist, there is no permit necessary to purchase it, and the substance can be readily purchased at most chemical-supply stores. But remember: Just because you can get your hands on it, doesn’t mean you can use it like they do in the movies.
Is chloroform illegal in India?
There is haze on the legality of online chloroform sale. Amrut Nikhade, joint commissioner (headquarters), Food and Drug Administration (FDA), said, “Chloroform comes under laboratory chemicals and hence, it is not considered a drug. It does not come under the purview of the department.
Which spray is used for sleeping?
ZOLPIDEM (zole PI dem) is used to treat insomnia. This medicine helps you to fall asleep and sleep through the night.