What is ERBB2 in cancer?
ErbB2 plays an important role in human malignancies. The erbB2 gene is amplified or overexpressed in approximately 30% of human breast cancers9 and in many other cancer types, including ovarian,9 stomach,10 bladder,11 salivary,12 and lung carcinomas.
What is the gene code for HER2?
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene.
Is it better to have HER2 positive or negative?
Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than breast cancers that are HER2-negative, but are much more likely to respond to treatment with drugs that target the HER2 protein.
What cancers can be HER2 positive?
Cancers that may be HER2 positive include breast, bladder, pancreatic, ovarian, and stomach cancers. Also called c-erbB-2 positive and human epidermal growth factor receptor 2 positive.
Are you born with HER2-positive?
HER2-positive breast cancer is not inherited. Instead, it’s considered a somatic genetic mutation. This type of mutation occurs after conception. Having a close relative with HER2-positive breast cancer does not increase your risk for breast cancer or HER2-positive breast cancer.
Is ERBB2 an RTK?
The ERBB family of RTKs consists of four members, EGFR (epidermal growth factor receptor, also known as ERBB1/HER1), ERBB2 (HER2), ERBB3 (HER3), and ERBB4 (HER4), cytoplasmic membrane-anchored proteins that share structural and sequence similarities, containing an extracellular ligand-binding domain, a transmembrane …
Is HER2 equivocal positive or negative?
If the IHC result is 3+, the cancer is HER2-positive. These cancers are usually treated with drugs that target HER2. If the IHC result is 2+, the HER2 status of the tumor is not clear and is called “equivocal.” This means that the HER2 status needs to be tested with FISH to clarify the result.