What does high proliferation rate mean?
A high percentage means that the breast tumor is more likely to be aggressive and spread quickly.
What does low proliferation rate mean?
Proliferation rate provides more information about how fast the cancer cells are dividing. Doctors commonly use a measure called “Ki-67” to describe the proliferation rate. A low Ki-67 percentage means slowly dividing cells, and a high Ki-67 (over 20%) means quickly dividing cells.
What is considered a high proliferation index?
Results: High Ki-67 proliferative index, defined as greater than 30% tumor cells showing nuclear immunoreactivity, was significantly more frequent in the DOD group than in the NED group and was associated with tumor-related mortality (P = 0.02).
How do you calculate proliferation?
Proliferation index is calculated as the sum of the cells in all generations including the parental divided by the computed number of original parent cells theoretically present at the start of the experiment.
What is cell proliferation rate?
Cell proliferation is defined as the cellular growth rate or as the quantified value for the daughter cell population (Gratzner, 1982).
Is HER2 negative good?
In normal cells, HER2 helps control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface.
What is a high Ki-67 proliferation index?
High Ki-67 proliferative index, defined as greater than 30% tumor cells showing nuclear immunoreactivity, was significantly more frequent in the DOD group than in the NED group and was associated with tumor-related mortality (P = 0.02).
What is cell growth rate?
The most common measurement for cell culture growth rate is the so-called population doubling time (PDT), i.e. the time it takes for a population to double its size [8]. The doubling time can be estimated from the population size at two points [8]. For cells growing exponentially this value is well-defined.
What causes cells to proliferate?
Cell proliferation occurs by combining cell growth with regular “G1-S-M-G2” cell cycles to produce many diploid cell progeny. In single-celled organisms, cell proliferation is largely responsive to the availability of nutrients in the environment (or laboratory growth medium).