What drugs are Akt inhibitors?
Several AKT inhibitors have been recently developed and two ATP-competitive compounds, capivasertib and ipatasertib, have been extensively tested in phase I and II clinical trials either alone, with chemotherapy, or with hormonal agents.
What happens if Akt is inhibited?
Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells.
How does Akt inhibit apoptosis?
Akt inhibits apoptosis induced by microinjection of cytochrome c and lysates from cells expressing active Akt inhibit cytochrome c induced caspase activation in a cell-free assay while lysates from Bcl-2–expressing cells have no effect.
What is AKT treatment?
Treatment of Tuberculosis (TB) Akt 4 Kit is a combination of medicines that is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection.
What is an ATR inhibitor?
It is an ATR inhibitor, a promising class of new drugs that target the ATR (ataxia telangiectasia mutated and Rad3-related) kinase, which is involved in DNA damage repair. The drug inhibits the growth of tumor cells by limiting their ability to repair damaged DNA.
What is the function of Akt?
The action of Akt on its downstream targets determines its function in cardiovascular processes such as cell survival, growth, proliferation, angiogenesis, vasorelaxation, and cell metabolism. Akt promotes cell survival via caspase-9, YAP, Bcl-2, and Bcl-x activities.
How many days AKT 4 should be taken?
AKT 4 is usually taken for 2 to 3 months and then maintenance therapy with 2 drugs for 4 to 6 months. That is the standard antitubercular treatment. The liver function needs to be monitored regularly during this times as the meds may affect liver. The symptoms could be due to deranged LFT.
What is Akt disease?
Dysregulation of Akt leads to diseases of major unmet medical need such as cancer, diabetes, cardiovascular and neurological diseases. As a result there has been substantial investment in the development of small molecular Akt inhibitors that act competitively with ATP or phospholipid binding, or allosterically.
Is Akt an enzyme?
A group of enzymes involved in several processes related to cell growth and survival. Akt enzymes help to transfer signals inside cells. An Akt enzyme is a type of serine/threonine protein kinase.
Is AKT 4 A antibiotic?
Drug Name : Isoniazid Isoniazid(Tubizid) generic AKT 4 is an antibiotic agent, prescribed for tuberculosis (TB) either alone or with other medications. It works by killing TB organisms.
What are the side effects of AKT 4 tablet?
Common side effects of Akt 4
- Nausea.
- Vomiting.
- Rash.
- Fever.
- Dark colored urine.
- Sweating.
- Increased sputum production.
- Salivation.