What is recombinant interleukin?
Recombinant human interleukin-2 is a form of interleukin-2 that is made in the laboratory. Recombinant human interleukin-2 increases the activity and growth of white blood cells called T lymphocytes and B lymphocytes, which may help the immune system kill cancer cells.
What does IL-15 do to T cells?
IL-15 induces the activation, the proliferation and the survival of T cells and contributes to generation and maintenance of high-avidity, antigen-specific CD8+ memory T cells in the long-term. In addition, IL-15 is involved in the development, the persistence and the activation of NK and NKT as well as γ/δT cells (2).
Is IL-15 pro or anti inflammatory?
IL-15 is a pro-inflammatory cytokine that is best characterized for its effects on T-lymphocyte and NK-cell activation, proliferation, and survival (4, 5).
Do dendritic cells produce IL-15?
IL-15, secreted by IL-15 dendritic cells (DCs), provides an important signal for DC-mediated γδ T cell proliferation and IFN-γ production.
Is IL-15 inflammatory?
Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.
When was il2 made?
IL-2, produced by T cells during an immune response,121 is necessary for the growth, proliferation, and differentiation of naïve T cells into effector T cells.
What is interleukin treatment?
Immunotherapy is cancer treatment that stimulates the body’s immune system to fight cancer, such as melanoma. Interleukin-2 is systemic therapy, which means that the treatment reaches all parts of your body through the bloodstream.
What does interleukin do in the body?
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukins regulate immune responses. Interleukins made in the laboratory are used as biological response modifiers to boost the immune system in cancer therapy. An interleukin is a type of cytokine.
How is IL-15 produced?
Although IL-15 is mainly produced by macrophages it is also produced by MNGC and endothelial cells of the blood vessels. The IL-15 produced by the endothelial cells may attract T cells and sustain their growth in the interface membrane.