What drug class is NIMBEX?
Nimbex is a prescription medicine used to before general anesthesia in preparation for surgery. Nimbex may be used alone or with other medications. Nimbex belongs to a class of drugs called Neuromuscular Blockers, Nondepolarizing.
How is TOF ratio calculated?
The TOF ratio is calculated by comparing the magnitude of the fourth evoked response or twitch (T4) to that of the first response (T1). During partial nondepolarizing block, T4 decreases preferentially, such that there is fade (i.e., TOF ratio less than 1.0). In the illustration above, the TOF ratio = 0.40 (40%).
What is the other name for NIMBEX?
Cisatracurium besilate
| Clinical data | |
|---|---|
| Trade names | Nimbex |
| Other names | 51W89, cisatracurium besylate (USAN US ) |
| AHFS/Drugs.com | Monograph |
| License data | US DailyMed: Cisatracurium_besylate |
What is NIMBEX used for?
Nimbex can be used as an adjunct to general anaesthesia, or sedation in the Intensive Care Unit (ICU) to relax skeletal muscles, and to facilitate tracheal intubation and mechanical ventilation.
Can you give succinylcholine twice?
A longer-acting paralytic affords us time to secure the airway even in the more difficult cases without sending a nurse scrambling for a second dose of succinylcholine. Finally, repeat doses of succinylcholine increase the risk of its adverse effects (masseter spasm, hyperkalemia).
What is the reversal agent for NIMBEX?
Reversal. Neuromuscular block following Nimbex administration is readily reversible with standard doses of anti-cholinesterase agents.
Is propofol and NIMBEX compatible?
Interactions between your drugs No interactions were found between Nimbex and propofol.
Why is Nimbex used in ICU?
NIMBEX® (cisatracurium besylate) is indicated as an adjunct to general anesthesia to facilitate tracheal intubation in adults and in pediatric patients 1 month to 12 years of age; to provide skeletal muscle relaxation in adults during surgical procedures or mechanical ventilation in the ICU; and to provide skeletal …
Can Nurses push Nimbex?
May be administered IV direct or by IV infusion by a nurse in Adult Critical Care providing that the patient is receiving full mechanical ventilation. A nurse in Adult Critical Care may administer the initial dose.
What is train of four used for?
‘Train of four’ test is a test routinely used during the surgery, which is performed by stimulation of peripheral nerve with purpose to determine the degree of muscle relaxation by interpretation of muscle response.
When do you use train of four?
What is a Phase 2 block with succinylcholine?
Succinylcholine, if administered in higher concentrations or as a continuous infusion (usually total greater than 4 mg/kg) can also result in what is called a “Phase II block.” After the neuromuscular membrane has been depolarized, due to the activity of Na-K channels, the membrane continuously moves back in the …
How long does NIMBEX stay in your system?
Spontaneous Recovery. Once recovery from neuromuscular block is underway, the rate is independent of the Nimbex dose administered. During opioid or halothane anaesthesia, the median times from 25 to 75% and from 5 to 95% recovery are approximately 11 and 28 minutes, respectively.
Can you bolus NIMBEX?
After administration of an initial bolus dose of NIMBEX, a diluted solution of NIMBEX can be administered by continuous infusion to adults and children aged 2 or more years for maintenance of neuromuscular block during extended surgical procedures. Infusion of NIMBEX should be individualized for each patient.