What is DCR in oncology?
Abstract. Disease Control Rate (DCR) and Clinical Benefit Rate (CBR) are defined as the percentage of patients with advanced or metastatic cancer who have achieved complete response, partial response and stable disease to a therapeutic intervention in clinical trials of anticancer agents.
What is Recist in oncology?
Listen to pronunciation. A standard way to measure how well a cancer patient responds to treatment. It is based on whether tumors shrink, stay the same, or get bigger. To use RECIST, there must be at least one tumor that can be measured on x-rays, CT scans, or MRI scans.
What is CR rate in cancer?
Complete response to treatment (CR) is the term used for the absence of all detectable cancer after your treatment is complete. Complete response doesn’t necessarily mean that you are cured, but it is the best result that can be reported. It means the cancerous tumor is now gone and there is no evidence of disease.
What is the difference between ORR and DCR?
Objective response rate (ORR)Percentage of patients whose disease decreased (Partial response – PR) and/or disappears (Complete response – CR) after treatment. Disease control rate (DCR) or clinical benefit rate (CBR) Percentage of patients whose disease shrinks or remains stable over a certain time period.
What is DoR clinical trial?
Duration of response, or DoR, is the length of time that a tumor continues to respond to treatment without the cancer growing or spreading. Cancer drugs that demonstrate improved DoR can produce a durable, meaningful delay in disease progression, as opposed to a temporary response without any lasting benefit.
Is CR Complete remission?
A CR (also called complete remission) is the disappearance of all signs of cancer in response to treatment. This does not always mean the cancer has been cured.
Does remission mean cured?
Cure means that there are no traces of your cancer after treatment and the cancer will never come back. Remission means that the signs and symptoms of your cancer are reduced. Remission can be partial or complete. In a complete remission, all signs and symptoms of cancer have disappeared.
What is ORR and CR?
Two types of response rates are commonly used to measure tumor response to treatment in oncology clinical trials: objective response rate (ORR) and complete response (CR) rate (also known as pathologic complete response) (FDA 2007).
How are oncology clinical trials different?
Oncology is somewhat more complicated than other therapeutic areas. The endpoints, for one, differ greatly. For example, rather than running a clinical trial to test the safety and efficacy of an antibiotic against an infection, an oncology trial is trying to extend and improve a subject’s quality of life.
Is Gleason 7 prostate cancer serious?
A Gleason score of 7 is a medium-grade cancer, and a score of 8, 9, or 10 is a high-grade cancer. A lower-grade cancer grows more slowly and is less likely to spread than a high-grade cancer. Doctors look at the Gleason score in addition to stage to help plan treatment.