What is another name for tenofovir?
Tenofovir DF (brand name: Viread) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 2 years of age and older who weigh at least 22 lb (10 kg). Tenofovir DF is always used in combination with other HIV medicines.
Is tenofovir water soluble?
Tenofovir disoproxil fumarate is a white to off-white crystalline powder with a solubility of 13.4 mg/mL in distilled water at 25 °C.
What is meaning of tenofovir disoproxil fumarate?
A pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir disoproxil fumarate is prescribed to treat HIV and chronic hepatitis B virus (HBV) in adults. Synonym: PMPA prodrug.
What type of drug is tenofovir?
Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV and HBV in the blood.
What is TDF and TAF?
Tenofovir disoproxil fumarate (TDF) is an antiretroviral (ARV) medication approved in 2001 to prevent and treat HIV, and in 2008 to treat chronic hepatitis B. Tenofovir alafenamide (TAF) is a new and improved formulation of tenofovir, approved in 2015.
How does tenofovir cause renal failure?
Proximal tubular cell secretion of tenofovir explains the accumulation of the drug in these mitochondria-rich cells. Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease.
Does tenofovir cause infertility?
While there were some limitations, including a lack of data on seminal parameters and conception intentions, the authors concluded that tenofovir-based PrEP does not have adverse effects on the fertility of HIV-negative men or the subsequent pregnancy outcome.
Why is tenofovir a pro drug?
By enhancing stability in biological matrices while being rapidly activated in cells, TAF produces higher levels of intracellular TFV diphosphate, the pharmacologically active metabolite, in HIV-target cells at substantially reduced oral doses of TFV equivalents.
What is disoproxil fumarate used for?
EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE (em tri SIT uh bean; te NOE fo veer) is 2 antiretroviral medicines in 1 tablet. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.
What is disoproxil used for?
What is this medicine? EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE (em tri SIT uh bean; te NOE fo veer) is 2 antiretroviral medicines in 1 tablet. It is used with other medicines to treat HIV.
Is TAF or TDF better?
TDF is generally safe and well tolerated, but it can cause kidney problems and bone loss in some people. TAF has less effect on the kidneys and bones. On the other hand, TDF leads to lower cholesterol and triglyceride levels, which can lessen cardiovascular risk.
Which ARV is TAF?
Tenofovir alafenamide (TAF) is an orally bioavailable form of tenofovir (TFV). TAF is available as a 25 mg single drug tablet for use in hepatitis B and at a dose of 25 mg in several fixed-dose combination tablets without cobicistat for use in HIV.
Does tenofovir increase creatinine?
Percentage increase in creatinine after introduction of tenofovir with dolutegravir ranged from 12% to 111%.
What is disoproxil fumarate?
Tenofovir Disoproxil Fumarate is a water soluble diester prodrug of the active ingredient tenofovir. The oral bioavailability of tenofovir from Tenofovir Disoproxil Fumarate in fasted subjects is approximately 25%.
What are the forms of tenofovir disoproxil?
DOSAGE FORMS & STRENGTHS. Tenofovir Disoproxil Fumarate is available as tablets. Tenofovir Disoproxil Fumarate tablets contain 300 mg of Tenofovir Disoproxil Fumarate, which is equivalent to 245 mg of tenofovir disoproxil. The tablets are white, almond shaped, film coated debossed with ‘H’ on one side and ‘123’ on other side.
Does tenofovir disoproxil fumarate cause renal impairment?
Inform patients that renal impairment, including cases of acute renal failure and Fanconi syndrome, has been reported in association with the use of Tenofovir Disoproxil Fumarate.
What is the generic name for tenofovir?
It is sold under the trade name Viread.Reference standards of Tenofovir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below. ( ( ( ( (1- (6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl) (isopropoxy)phosphoryl)oxy)methyl Isopropyl Carbonate