What do you monitor with statins?
The ATP III recommendations for monitoring of statin therapy are as follows: check lipid panel at baseline, 6–8 weeks after starting or adjusting the medication/dose, and then every 4–6 months; check LFTs at baseline, approximately 12 weeks after starting therapy, then annually or more frequently if indicated; and …
What labs should be monitored with atorvastatin?
Patients starting atorvastatin should have liver function tests and a lipid panel performed at baseline, with a repeat lipid panel after six weeks on therapy. Liver function tests should be repeated as clinically indicated. Once the patient is stable, lipids can be checked every 6 to 12 months.
Do you need to monitor LFTs on statins?
Current liver function testing for statin monitoring is largely unnecessary and costly. Statins do not cause liver disease. Both reduction in test frequency and use of a single alanine transaminase (ALT) rather than a full seven analyte liver function test (LFT) array would reduce cost and may benefit patients.
When do you recheck labs after starting statin?
After starting a statin, it takes about six weeks for cholesterol levels to stabilise, so most doctors would re-check your cholesterol after about eight weeks. You should have a check-up at least once a year or more often if your doctor thinks it is necessary.
Can statins raise AST and ALT levels?
Our results indicate that statins do cause borderline elevation of LFTs overtime. These abnormalities are dose dependant; patients using atorvastatin 40 mg/day had greater elevations for both ALT and AST as compared to rosuvastatin 20 mg/day.
Do statins affect CK levels?
Statins can magnify exercise-induced marked elevation of the CK.
Can statins raise LFT?
Statins cause dose-dependent borderline elevations of liver function tests over time. These elevations are clinically and statistically insignificant and should not deter physicians from prescribing or continuing statins.
When do you repeat lipid panel after starting statin?
medications and lifestyle changes with repeat lipid measurement 4 to 12 weeks after statin initiation or dose adjustment, repeat- ed every 3 to 12 months as needed.
Can statins elevated LFTs?
Do statins raise GGT levels?
Statins can inhibit the expression of GGT in atheromatous plaque of local tissue, which leads to a decrease in oxidative stress in the plaque. This may promote the stabilization of atherosclerotic plaque and reduce the incidence of cardiovascular events.
Can statins lower CK levels?
After 1.2 months of follow-up in 29 statin–>statin patients, median CK fell from 353 to 301 (P = . 0018) and was 287 (P = . 015) after 4 months. After 1.3 months of follow-up in 20 no statin–>statin patients, median CK fell from 397 to 292 (P = .
Do statins cause elevated ALT?
Statins increase alanine aminotransferase (ALT) concentrations in 10% of recipients, and this increase can exceed more than three times the upper limit of normal in 1% of patients.
Do statins raise CPK levels?
Large clinical trials have established that statins are effective in the primary and secondary prevention of coronary heart disease 1,2. However, their use is associated with muscle pains, raised creatine phosphokinase (CPK) and rarely with rhabdomyolysis, which can be fatal 3.
Do statins affect ALT levels?
Can statins raise AST and ALT?
How do you monitor statin therapy?
Monitoring statin therapy Fasting lipid profile: At 6-8 weeks after starting or with medication change and then every 6-12 mos. Liver enzymes: ALT (not AST) within the first 3 months. If normal no further testing unless symptoms develop or statin increased or switched.
Do GPS in Italy comply with the Recommended laboratory monitoring for statins?
Adherence to the recommended laboratory monitoring for statin users is very low among Italian GPs, even for high-risk patients. Automatic reminders which pop-up whenever statins are prescribed are ineffective. Monitoring statin safety in primary care Pharmacoepidemiol Drug Saf. 2007 Jun;16(6):652-7.doi: 10.1002/pds.1361.
When should liver enzyme tests be performed during statin therapy?
Healthcare professionals should perform liver enzyme tests before initiating statin therapy in patients and as clinically indicated thereafter. If serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs during treatment, therapy should be interrupted.
Should we monitor liver biochemistries in asymptomatic patients receiving statins?
FDA reviewed current monitoring guidelines, including the National Lipid Association’s Liver Expert Panel and Statin Safety Task Force recommendations. 1, 2 The Liver Expert Panel stated that the available scientific evidence does not support the routine monitoring of liver biochemistries in asymptomatic patients receiving statins.