What are the side effects of diltiazem cream?
The side effects reported with 2% diltiazem topical are mild headache, perianal itching and perianal dermatitis. The reports of headaches are less with diltiazem than with glyceryl trinitrate ointment.
Is diltiazem cream safe?
Based on the studies, diltiazem cream or ointment does not appear to cause significant harm or side effects in adults using it in the short term. Most studies looked at use for around 3 months or less. It is not known what possible harms or side effects the treatment may cause if it is used for longer than this.
How long does diltiazem take to heal fissure?
RESULTS: In 39 patients (13 males; median age, 42 (range, 20– 80) years), topical 2 percent diltiazem gel lowered anal resting pressure by 20 percent from a median of 93 to 74 cm H2O (P < 0.0001, Wilcoxon), and fissures healed in 19 (49 percent) within 8 weeks.
How long does it take diltiazem cream to work?
In keeping with earlier reports[11-13], topical 2% diltiazem gel in this study provided earlier pain relief, with a significant reduction in pain after 1 wk and preceded the significant healing rate of chronic anal fissure observed at 6 wk of treatment.
How effective is diltiazem cream?
Conclusion: This study shows that topical 2% diltiazem is an effective and safe treatment for chronic anal fissure in patients who have failed topical 0.2% GTN. The need for sphincterotomy can be avoided in up to 70% of cases.
Does diltiazem cream need to be refrigerated?
Do not store or use the cream after the expiry date. Store in a refrigerator, away from direct heat and light.
Where do you apply diltiazem ointment?
Diltiazem hydrochloride 2% cream works by relaxing the muscle around the anus (the anal sphincter), thereby reducing the anal pressure and increasing the blood flow to the area to allow healing to occur. Apply a small amount to your finger (approximately 2.5cm) and place the cream just inside the anus, at the entrance.
Can diltiazem cure fissure?
Does itching mean fissure is healing?
It may be noticed when cleaning the rectal area. Itching: Discharge may result as the fissure alternately heals and reopens, causing itching.
What is the fastest way to heal a fissure?
Most anal fissures heal naturally with the aid of proper nutrition and lifestyle habits. The following methods may help speed the healing process ( 1 ): using over-the-counter stool softeners. taking a sitz bath for 10–15 minutes, especially after bowel movements.
Does Preparation H work on fissures?
Living with anal fissures Your doctor may prescribe stool softeners to make going to the bathroom easier and less painful while the fissure heals. Numbing cream can also make bowel movements less painful. Petroleum jelly, zinc oxide, 1% hydrocortisone cream, and products like Preparation H can help soothe the area.
Does diltiazem cause stomach problems?
If experienced, these tend to have a Less Severe expression i. indigestion. constipation. dizziness. difficulty sleeping. temporary redness of face and neck. headache. nausea. diarrhea.
Does diltiazem cause weight loss?
Weight loss is found among people who take Diltiazem hydrochloride, especially for people who are female, 60+ old. The phase IV clinical study analyzes which people take Diltiazem hydrochloride and have Weight loss.
Does diltiazem cause liver damage?
There have been reports of liver damage within the first eight weeks of diltiazem (Cardizem), particularly if you have a history of liver disease. Your doctor could monitor you for liver damage with blood tests. Interactions between diltiazem (Cardizem) and other medications
Can diltiazem cause health issues if inhaled?
This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Diltiazem is a calcium channel blocker.