How is vancomycin dosed?
Typically 15 to 20 mg/kg every 8 to 12 hours for most patients (based on actual body weight, rounded to the nearest 250 mg increment).
How is vancomycin AUC MIC calculated?
The empiric AUC:MIC ratio for a vancomycin dosing regimen can be predicted in advance by a simple formula: First, divide the total daily dose of vancomycin by the estimated clearance of vancomycin. Then divide this number by the MIC.
How do you calculate vancomycin interval?
Matzke’s method using actual (total) body weight (TBW) was ranked second:
- CLvanco (mL/min) = (CrCl× 0.689) + 3.66.
- Vd = 0.72 L/kg if CrCl is >60 mL/min.
- Vd = 0.89 L/kg if CrCl is 10 to 60 mL/min.
- Vd = 0.9 L/kg if CrCl is less than 10 mL/min.
How do you calculate vancomycin infusion rate?
- Administration of vancomycin by continuous infusion.
- Loading dose.
- Dose (in mg) = Target concentration (in mg/L) x Volume of distribution (in L/kg)
How do you take vancomycin 4 times a day?
Take the capsules exactly as your doctor tells you to. It is usual to take one (125 mg) capsule four times a day for 10-14 days. In serious infections, the dose could be as high as 500 mg four times a day for 10-14 days.
What weight do you use for vancomycin?
Current guidelines for systemic vancomycin dosing and monitoring recommend calculating initial doses (15–20 mg/kg every 8–12 hours) using actual body weight (ABW), regardless of BMI, followed by therapeutic drug monitoring for dose adjustments [3].
What is AUC MIC dosing of vancomycin?
The area under the curve (AUC) over 24 hours/minimum inhibitory concentration (MIC) of ≥ 400 best predicts the efficacy of vancomycin, and a trough vancomycin serum concentration between 15 and 20 mg/L has been shown to achieve an AUC/MIC ≥ 400 when the MIC is ≤ 1 in adult patients.
What weight do you use for vancomycin dosing?
How is vancomycin given IV?
Vancomycin injection comes as a powder to be added to fluid and injected intravenously (into a vein). It is usually infused (injected slowly) over a period of at least 60 minutes once every 6 or 12 hours, but may be given every 8 hours in newborn babies.
How do you reconstitute vancomycin 1g?
At the time of use, reconstitute by adding either 10 mL of Sterile Water for Injection to the 500-mg vial or 20 mL of Sterile Water for Injection to the 1-g vial of dry, sterile vancomycin powder.
What does AUC dosing mean?
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.
When do you draw peak and trough for vancomycin?
Do not draw specimens until steady state is achieved (ie, before fourth dose) Draw trough specimen immediately before (≤30 min) next dose. Draw peak specimen 1-2 hours after completion of intravenous dosage.
When are vancomycin trough levels drawn?
The 2020 vancomycin dosing guidelines now recommend a different dosing regimen. A Bayesian approach allows vancomycin levels to be drawn within the first 24 to 48 hours instead of waiting for steady-state conditions (after the 3rd or 4th dose). This information can be used to change subsequent dosing.
How to calculate Vanco AUC?
How To Calculate AUC 24 for Vancomycin. AUC24 is calculated using either Bayesian modeling, which falls outside the scope of this document, or a more transparent “trapezoidal” model, which calculates AUC through the measurement of two trapezoids which fill most of the area under the curve.
What is the dosage of vancomycin?
The usual dose is 40 milligrams per kilogram (mg/kg) of body weight, divided into 3 or 4 doses, and taken for 7 to 10 days. However, dose is usually not more than 2000 mg per day. Adults—500 to 2000 milligrams (mg) divided into 3 or 4 doses for 7 to 10 days.
When to check Vanco level?
Vancomycin. A vancomycin trough level should be obtained within 1 hour of the dose: Gestational age ≥ 30 weeks, obtain level prior to the administration of the 3rd dose. Gestational age < 30 weeks, obtain level prior to the administration of the 2nd dose. If impaired renal function is a concern, a level should be obtained before the 2nd dose.
When to order Vanc trough?
Typically, the medication reaches peak concentration between one and two hours after administration. Depending on the size of the dose, the patient’s general health, and other factors, the timing of the trough may vary. A doctor can request a peak reading after administration and check back to see when the patient hits the trough.