What does sialyl Lewis bind to?
Sialyl-Lewisx allows a sperm cell to recognize and fertilize an egg cell. For fertilization to occur, human sperm must bind to the zona pellucida (ZP), the translucent matrix covering the human egg composed of four glycoproteins ZP1, 2, 3, and 4, and transit through the matrix in order to fuse with the oocyte.
Where is E-selectin produced?
The local release of cytokines IL-1 and TNF-α by Macrophages in the inflamed tissue induces the over-expression of E-selectin on endothelial cells of nearby blood vessels.
What are selectin receptors?
Abstract. The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.
Where are Lex-related epitopes expressed in the brain?
Both LeX-related epitopes are expressed primarily in the embryonic cortex, whereas immunoreactivity in the medial and lateral GE was reduced (Fig. 5, B–D).
What is Sialyl Lewisx?
Sialyl LewisX, also known as sialyl LeX or SLeX, is a tetrasaccharide carbohydrate with the sequence Neu5Acα2-3Galβ1-4[Fucα1-3]GlcNAcβ- that is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.
What studies led to the discovery of Sialyl lewis x?
The studies done on these individuals’ red blood cells led to the discovery of sialyl Lewis X. Sialyl Lewis x is a very important red blood cell antigen present on the glycolipids on the plasma membrane of the cell. Its localization on the cell surface of cells led to its alternative nomenclature as a cluster of differentiation.
Can sialyl Lewis X be used to detect cancer cells?
It has been shown that there is frequent overexpression of sialyl Lewis x on cancer cells and is found on both N-glycan and O-glycans. Sialyl Lewis x is being researched with CD markers to find new ways to create biosensors for cancer cells.