Which of the following treatments would be used for flecainide overdose?
High-dose hypertonic sodium bicarbonate is the mainstay of medical therapy of flecainide overdose and should be dosed aggressively (initial 50–100 mEq bolus with subsequent therapy to get pH > 7.5 and sodium concentration > 150 mEq/L).
What happens if you overdose on flecainide?
Flecainide overdose can rapidly cause arrhythmias and shock, which if refractory to medications (antiarrhythmics, vasopressors) and electricity (pacing, cardioversion) will require mechanical circulatory support, most commonly venoarterial extracorporeal membrane oxygen (VA-ECMO).
Can flecainide affect your lungs?
Our report describes the first acute presentation of flecainide-induced lung injury. Although drug-induced lung injury from flecainide is rare, clinical recognition of this phenomenon is important because prolonged flecainide exposure may lead to severe or potentially fatal pulmonary compromise.
How much flecainide is too much?
Adults—At first, 100 milligrams (mg) every 12 hours. Your doctor may increase your dose as needed. However, the dose is usually not more than 400 mg per day.
Can flecainide cause sudden death?
The CAST trial [4, 5] reported a 2.5-fold increased risk of sudden cardiac death (SCD) in patients treated with flecainide/encainide compared with placebo in a population with structural heart disease.
Can flecainide cause death?
Flecainide-induced arrhythmias include sinus bradycardia or arrest in 2%, bundle branch blocks in 1%, increased premature ventricular depolarizations in 1%, ventricular tachycardia or fibrillation in 0.5%, and sudden death in 0.2% of patients.
Which adverse effect is most common in a patient who is taking flecainide?
Dizziness, vision problems (such as blurred vision, problems focusing, seeing spots), headache, nausea, shaking, tiredness, or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Can flecainide damage the heart?
There is a chance that flecainide may cause new or make worse existing heart rhythm problems when it is used. Since it has been shown to cause severe problems in some patients, it is only used to treat serious heart rhythm problems.
Which is safer amiodarone or flecainide?
Overall, these analyses suggest that acute and chronic therapy with flecainide does not confer a mortality benefit or risk compared with controls in patients with AF, but that flecainide may confer a lower mortality risk compared with sotalol and amiodarone.
Is flecainide a high risk drug?
This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. If you’ve had a heart attack within the past two years, flecainide may raise your risk of having another heart attack, which can be fatal.