What feature of a pleomorphic adenoma could potentially contribute to a recurrence post treatment?
Pathology-related variables associated with recurrence include the histological subtype, the thickness and incompleteness of the tumor capsule, pseudopodia, and satellite nodules. Surgery-related variables associated with recurrence are the presence of intact margins and tumor puncture or spillage.
Do pleomorphic adenomas grow back?
Pleomorphic adenoma (PA) is the most common tumour of the salivary glands, and can recur even after proper surgery. The extent and timing of surgery for recurrent tumours remains controversial, and multiple recurrences pose a special challenge.
How can you prevent pleomorphic adenoma recurrence?
One strategy to reduce the rate of recurrence is to re-evaluate surgical margins using intraoperative frozen sections. In addition, the optimal regimen should involve total parotidectomy, rather than enucleation or superficial parotidectomy [1,2,4]. Zernial et al.
Can a pleomorphic adenoma become malignant?
Pleomorphic adenomas harbor a small risk of malignant transformation. The malignant potential is proportional to the time the lesion is in situ (1.5% in the first five years, 9.5% after 15 years). Therefore, excision is warranted in almost all cases.
Can pleomorphic adenoma metastasis?
Although pleomorphic adenoma is a benign tumor, it can metastasize especially when the excision was incomplete. The most frequent primary site of a metastasizing pleomorphic adenoma is the parotid gland, where complete excision is difficult due to critical anatomical problems such as the presence of the facial nerve.
Can salivary gland tumor come back?
People with cancer of the salivary gland are at risk of the cancer coming back and are at risk for developing new cancers in the head and neck area, so they must be watched closely after treatment.
Can a parotid gland tumor come back?
Parotid tumors can recur as a single solitary mass or the recurrence may present as a large cluster of separate tumors.
Do parotid tumors grow back?
What percentage of pleomorphic adenomas become malignant?
What is metastatic adenoma?
Metastatic adenocarcinomas can originate in various parts of the body, such as the thyroid gland. Alamy. Adenocarcinoma is a type of cancer that forms in mucus-secreting gland cells, which are found in tissues that line internal organs. When adenocarcinoma spreads from the initial site, it is described as metastatic. (
Do pleomorphic adenomas disappear?
Although it is classified as benign, a pleomorphic adenoma can undergo a malignant transformation, with a tendency to recur. In 5% of cases, in fact, if it is not surgically removed, a pleomorphic adenoma can degenerate into a carcinoma (taking the name of Carcinoma ex Pleomorphic Adenoma).
Is squamous metaplasia reversible?
Metaplasia is reversible when the stimulus for it is taken away. Dysplasia: a disordered growth and maturation of an epithelium, which is still reversible if the factors driving it are eliminated.