Is eravacycline FDA approved?
The US Food and Drug Administration (FDA) has approved eravacycline (Xerava, Tetraphase Pharmaceuticals) for treatment of complicated intra-abdominal infections (cIAIs) in adults age 18 years and older, the company has announced.
What is an indication for eravacycline?
XERAVA is a tetracycline class antibacterial indicated for the treatment of. complicated intra-abdominal infections in patients 18 years of age and older. (1.1) Limitations of Use. XERAVA is not indicated for the treatment of complicated urinary tract.
Does eravacycline get into the urine?
Within 8 hours of the first IV dose of eravacycline, 1.5 mg/kg body weight, urinary concentrations of the drug were shown to be 4- to 14-fold higher than eravacycline’s MIC90 (0.5 µg/mL–2 µg/mL) to many common cUTI pathogens,60 although it is not active againstP.
Is eravacycline bacteriostatic?
Tetracyclines, including eravacycline, typically exhibit bacteriostatic activity; however, eravacycline also exhibits bactericidal activity against certain strains of Acinetobacter baumannii, E. coli and K. pneumoniae in vitro [11, 12].
Does eravacycline have anaerobic coverage?
In vitro, eravacycline exhibits potent activity against a broad spectrum of clinically relevant Gram-positive and -negative aerobic and anaerobic bacteria. Intravenous eravacycline is approved in several countries for the treatment of complicated intra-abdominal infections (cIAIs) in adult patients.
Does Eravacycline cover VRE?
Eravacycline has shown activity against many gram-positive organisms such as methicillin-resistant S. aureus and vancomycin resistant Enterococcus faecalis and Enterococcus faecium (VRE), gram-negative organisms such as Escherichia coli, and anaerobic species of microorganisms such as Bacteroides.
Does Eravacycline cover Pseudomonas?
Eravacycline demonstrates broad-spectrum antimicrobial activity against Gram-positive, Gram-negative, and anaerobic bacteria with the exception of Pseudomonas aeruginosa.
What is Xerava used for?
Eravacycline is used to treat certain abdominal infections (such as appendicitis, diverticulitis, gastric/intestinal perforation). This medication belongs to a class of drugs known as tetracycline antibiotics. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
Is Xerava an antibiotic?
Xerava (eravacycline) is a tetracycline antibiotic used to treat complicated intra-abdominal infections in patients 18 years of age and older.