What does tyrosine phosphatase do?
The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes.
What organism is YOPH from?
This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages….Details.
| Resource | Link |
|---|---|
| UniProtKB Entry Name | YOPH_YEREN |
What does protein tyrosine do?
Protein tyrosine (pTyr) phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability, and regulate enzyme activity.
Which disease shows increase levels of enzyme acid phosphatase?
Prostatic acid phosphatase (PAP), which is produced in the prostate, was the first major serum marker for prostate cancer. Metastasis of prostate cancer beyond the capsule, particularly to the bone, causes a rise in acid phosphatase level, with the level increasing in correspondence to the extent of the disease.
What disease is diagnosed by monitoring acid phosphatase activity?
This resulted in recurrent infections. Prostate acid phosphatase (PAP) has been used extensively as a serum marker for cancer of the prostate….Table 2.
| Human acid phosphatase (AP) | Clinical and laboratory importance |
|---|---|
| Prostatic (PAP) | Serum marker for cancer of the prostate15 |
What are the symptoms of Tyrosinemia?
Signs and symptoms often begin in early childhood and include eye pain and redness, excessive tearing, abnormal sensitivity to light (photophobia), and thick, painful skin on the palms of their hands and soles of their feet (palmoplantar hyperkeratosis).
What is the clinical significance of an elevated acid phosphatase?
Traditionally, the serum prostatic acid phosphatase has been thought to originate in the prostatic cancer cell and has been used to stage the disease. Until recently, elevated serum values have been accepted as an indication of extraprostatic disease, and were thought to rule out lesions confined to the prostate.
What is the clinical significance of acid phosphatase?
Which of the following diseases is related to tyrosine production or metabolism?
Five inherited disorders of tyrosine metabolism are known, which include tyrosinemia type I, type II, type III, hawkinsinuria and alkaptonuria. Newborn screening for these disorders has enabled their early detection and decreased the associated morbidity and mortality.