What is the role of interferon-gamma?
Interferon gamma (IFN-γ) is a cytokine critical to both innate and adaptive immunity, and functions as the primary activator of macrophages, in addition to stimulating natural killer cells and neutrophils.
What releases interferon-gamma?
IFN-γ is secreted by T helper cells (specifically, Th1 cells), cytotoxic T cells (TC cells), macrophages, mucosal epithelial cells and NK cells. IFN-γ is both an important autocrine signal for professional APCs in early innate immune response, and an important paracrine signal in adaptive immune response.
How do you reduce interferon-gamma?
Reducing your intake of alcohol may not only lower your IFN-gamma levels but also protect you from the well-known harmful effects of this substance [27]. Eat a diet high in omega-3 fatty acids may also help you lower your IFN-gamma levels, based on preliminary evidence in mice.
What cell produces interferon-gamma?
Interferon-gamma is secreted predominantly by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells (23–26), γδ T cells (27–33), and natural killer (NK) cells (34, 35) and, to a less extent, by natural killer T cells (NKT), B cells (36–39), and professional antigen-presenting cells ( …
What does interferon gamma do?
What is interferon gamma (IFNγ)?
From Wikipedia, the free encyclopedia Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
Is IL-17 a cytokine?
IL-17 is a newly identified T cell-specific cytokine [4,5]. The human IL-17 is a ∼20-kDa glycoprotein of 155 amino acids, the sequence of which exhibits close homology to both cytotoxic T lymphocyte-associated antigen-8 (CTLA-8) and the open reading frame 13 of T-lymphotropic Herpesvirus saimiri(HVS-13).
How do IFN-gamma and IL-17 interact with vascular smooth muscle cells?
Our findings demonstrate that IL-17 is produced concomitantly with IFN-gamma by coronary artery-infiltrating T cells and that these cytokines act synergistically to induce proinflammatory responses in vascular smooth muscle cells.
How are interleukin-17 and interferon-gamma produced?
Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells