Is carboplatin less toxic than cisplatin?
Carboplatin appears less toxic than cisplatin producing to date similar survival and response as a single agent.
Is cisplatin the strongest chemo drug?
Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical [20]. In ovarian germ cell cancer, the use of cisplatin brings about high response rates [21].
Why is cisplatin preferred over carboplatin?
Cisplatin and carboplatin have different toxicity profiles; cisplatin is associated with a higher rate of nausea, vomiting, nephrotoxicity, ototoxicity, while carboplatin has a higher risk of myelosupresssion and neurotoxicity6.
Why oxaliplatin is preferred over cisplatin?
Conclusions: Oxaliplatin-based regimen is superior to cisplatin-based regimen in tumour remission as first-line chemotherapy for advanced GC, and is associated with less toxicity and better tolerability.
Is carboplatin a platinum-based chemo?
Platinum-Based Drugs (Cisplatin, Carboplatin) These drugs form highly reactive platinum complexes that bind and crosslink DNA, a double-stranded molecule inside the nucleus of the cell that controls cellular activity. The chemical crosslinking within the DNA prevents cancer cells from growing and causes them to die.
How long does cisplatin side effects last?
Nausea and vomiting usually begin within 1 to 4 hours after treatment and last up to 24 hours. Various degrees of vomiting, nausea and/or anorexia may persist for up to 1 week after treatment.
Is cisplatin hard on your kidneys?
Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.
How many cycles of cisplatin can you have?
You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.
Is cisplatin better than carboplatin for palliative chemotherapy?
Meta-analyses of palliative chemotherapy indicate consistent survival advantages with cisplatin-based therapy over carboplatin; however, the relative advantage is small. Cisplatin carries a higher toxicity profile, including nausea, vomiting, neuropathy, renal insufficiency, and alopecia in comparison to carboplatin.
What are the platinum analogs of chemotherapy?
The platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladder cancer.
Is Taxotere better than cisplatin/Navelbine for survival?
The news from this trial was that the overall survival with cisplatin/taxotere was significantly better than the “control arm” of cisplatin/navelbine.
Was ist Chemotherapie in high-risk-EC?
Aktueller Stand der GOG-258-Studie Die US-amerikanische Gynecologic Oncology Group sieht bei High-Risk-EC aufgrund ihrer früheren randomisierten Studien die systemische Chemotherapie als die sinnvollste adjuvante Therapie für Patientinnen mit operiertem, lokal fortgeschrittenen EC an 6.